Review Article Comparative Analysis of the Omics Technologies Used to

License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Leishmaniasis is a serious threat in developing countries due to its endemic nature and debilitating symptoms. Extensive research and investigations have been carried out to learn about the mechanism of drug resistance in Leishmania but results obtained in the laboratory are not in agreement with those obtained from the field. Also the lack of knowledge about the mode of action for a number of drugs makes the study of drug resistance more complex. A major concern in recent times has been regarding the role of parasitic virulence in drug resistance for Leishmania. Researchers have employed various techniques to unravel the facts about resistance and virulence in Leishmania.With advent of advanced andmore specificmeans of detection, further hints about probable mechanisms of conferring resistance are expected. This review aims to provide a consolidated picture along with a comparative account of the work done so far to study the mechanism of antimony, amphotericin B, and pentamidine resistance using various techniques. 1. Leishmaniasis: Incidence, Cause, and Resistance Leishmaniasis forms the ninth largest disease burden in the world affecting more than 90 countries on every con-tinent except Antarctica and Australia (se