Add to ORKGCystic fibrosis airway epithelia exhibit a spectrum of ion transport properties that differ from normal, including not only defective cAMP-mediated Cl- secretion, but also in-creased Na+ absorption and increased Ca2"-mediated Cl-secretion. In the present study, we examined whether adeno-virus-mediated (Ad5) transduction of CFTR can correct all of these CF ion transport abnormalities. Polarized primary cultures of human CF and normal nasal epithelial cells were infected with Ad5-CBCFTR at an moi (104) which trans-duced virtually all cells or Ad5-CMV lacZ as a control. Con-sistent with previous reports, Ad5-CBCFTR, but not Ad5-CMV lacZ, corrected defective CF cAMP-mediated Cl- se-cretion. Basal Na + transport rates (basal I,q) in CF airw...
Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in a gene encoding a protein...
Background. Cystic fibrosis is characterized by abnormal electrolyte transport across the epithelia ...
Lung health relies on effective mucociliary clearance and innate immune defence mechanisms. In cysti...
Cystic fibrosis airway epithelia exhibit a spectrum of ion transport properties that differ from nor...
Cystic fibrosis (CF) airway epithelia exhibit defective trans-epithelial electrolyte transport: cAMP...
The transepithelial potential difference (PD) of cystic fibrosis (CF) airway epithelium is abnormall...
textabstractCystic fibrosis, an autosomal recessive disease frequently diagnosed in the Caucasian po...
Loss of cystic fibrosis transmembrane conductance regulator (CFTR) anion channel function causes cys...
The isolation of the gene responsible for the Cl- ion transport defect in cystic fibrosis (CF) has p...
1. Employing a primary cell culture system and intracellular microelectrodes, we quantitated and com...
In the respiratory system, Na(+) absorption and Cl(-) secretion are balanced to maintain an appropri...
SummaryDefective transepithelial electrolyte transport is thought to initiate cystic fibrosis (CF) l...
Abstract One of the most prevalent hypotheses pertaining to the sequence of events that lead to cyst...
Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in a gene encoding a protein...
Cystic fibrosis (CF) is a multi-organ autosomal recessive disease of fluid-transporting epithelia, d...
Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in a gene encoding a protein...
Background. Cystic fibrosis is characterized by abnormal electrolyte transport across the epithelia ...
Lung health relies on effective mucociliary clearance and innate immune defence mechanisms. In cysti...
Cystic fibrosis airway epithelia exhibit a spectrum of ion transport properties that differ from nor...
Cystic fibrosis (CF) airway epithelia exhibit defective trans-epithelial electrolyte transport: cAMP...
The transepithelial potential difference (PD) of cystic fibrosis (CF) airway epithelium is abnormall...
textabstractCystic fibrosis, an autosomal recessive disease frequently diagnosed in the Caucasian po...
Loss of cystic fibrosis transmembrane conductance regulator (CFTR) anion channel function causes cys...
The isolation of the gene responsible for the Cl- ion transport defect in cystic fibrosis (CF) has p...
1. Employing a primary cell culture system and intracellular microelectrodes, we quantitated and com...
In the respiratory system, Na(+) absorption and Cl(-) secretion are balanced to maintain an appropri...
SummaryDefective transepithelial electrolyte transport is thought to initiate cystic fibrosis (CF) l...
Abstract One of the most prevalent hypotheses pertaining to the sequence of events that lead to cyst...
Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in a gene encoding a protein...
Cystic fibrosis (CF) is a multi-organ autosomal recessive disease of fluid-transporting epithelia, d...
Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in a gene encoding a protein...
Background. Cystic fibrosis is characterized by abnormal electrolyte transport across the epithelia ...
Lung health relies on effective mucociliary clearance and innate immune defence mechanisms. In cysti...