Add to ORKGCopyright © 2013 Ilhuicamina Daniel Limón-Pérez de León et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A series of 1,3-substituted 8-styrylxanthines (11a-d) was synthesized, under chemo- and regioselective conditions, in a good overall yield. The compounds showed affinity towards both A1 and A2A-adenosine receptors by radioligand bind-ing by means of in vitro assays. The (E)-3-ethyl-1-propyl-8-styrylxanthine (11a) showed the greatest affinity towards the A2A receptor, whereas (E)-3-pentyl-1-propyl-8-styrylxanthine (11d) showed the greatest affinity for the A1 receptor....
Several studies have evidenced the opposite role played by dopamine and adenosine receptors in the c...
The present paper describes the synthesis of a series of 8-(cyclopentyloxy)phenyl-xanthines and thei...
Adenosine A2A receptor antagonists have emerged as an attractive non-dopaminergic target in clinical...
The adenosine A2A receptor is considered to be an important target for the development of new therap...
Based on a previous report that a series of 8-(phenoxymethyl)-xanthines may be promising leads for t...
The 8-substituted 9-ethyladenine derivatives: 8-bromo-9-ethyladenine (ANR 82), 8-ethoxy- 9-ethyladen...
Adenosine A1 receptors are attracting great interest as drug targets for their role in cognitive def...
A new series of 8-substituted 9-ethyladenine derivatives has been synthesized and tested at rat and ...
Clinical evidence has demonstrated that AA2AR antagonists could be an alternative approach to the tr...
Pharmacological studies implicate the blockade of adenosine receptorsas an effective strategy for re...
adenosine regulates a wide range of physiological functions through specific cell membrane receptors...
The potential of 8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-[3H]meth-ylxanthine ([3H]KF1 7837S) as a hig...
The most effective treatment of Parkinson's disease (PD) is, at present, the dopamine precursor L-3,...
A series of 8-substituted adenosine and theophylline-7-riboside analogues (28 and 9 compounds, respe...
Adenosine A(2A) receptor antagonists have emerged as an attractive non-dopaminergic target in clinic...
Several studies have evidenced the opposite role played by dopamine and adenosine receptors in the c...
The present paper describes the synthesis of a series of 8-(cyclopentyloxy)phenyl-xanthines and thei...
Adenosine A2A receptor antagonists have emerged as an attractive non-dopaminergic target in clinical...
The adenosine A2A receptor is considered to be an important target for the development of new therap...
Based on a previous report that a series of 8-(phenoxymethyl)-xanthines may be promising leads for t...
The 8-substituted 9-ethyladenine derivatives: 8-bromo-9-ethyladenine (ANR 82), 8-ethoxy- 9-ethyladen...
Adenosine A1 receptors are attracting great interest as drug targets for their role in cognitive def...
A new series of 8-substituted 9-ethyladenine derivatives has been synthesized and tested at rat and ...
Clinical evidence has demonstrated that AA2AR antagonists could be an alternative approach to the tr...
Pharmacological studies implicate the blockade of adenosine receptorsas an effective strategy for re...
adenosine regulates a wide range of physiological functions through specific cell membrane receptors...
The potential of 8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-[3H]meth-ylxanthine ([3H]KF1 7837S) as a hig...
The most effective treatment of Parkinson's disease (PD) is, at present, the dopamine precursor L-3,...
A series of 8-substituted adenosine and theophylline-7-riboside analogues (28 and 9 compounds, respe...
Adenosine A(2A) receptor antagonists have emerged as an attractive non-dopaminergic target in clinic...
Several studies have evidenced the opposite role played by dopamine and adenosine receptors in the c...
The present paper describes the synthesis of a series of 8-(cyclopentyloxy)phenyl-xanthines and thei...
Adenosine A2A receptor antagonists have emerged as an attractive non-dopaminergic target in clinical...