Partitioning glucose distribution/transport, disposal, and endogenous production during IVGTT

separated the effect of insulin on glucose distribution/transport, glucose disposal, and endogenous production (EGP) during an intravenous glucose tolerance test (IVGTT) by use of a dual-tracer dilution methodology. Six healthy lean male subjects (age 33 3 yr, body mass index 22.7 0.6 kg/m2) underwent a 4-h IVGTT (0.3 g/kg glucose enriched with 3–6 % D-[U-13C]glucose and 5–10 % 3-O-methyl-D-glucose) preceded by a 2-h investiga-tion under basal conditions (5 mg/kg of D-[U-13C]glucose and 8 mg/kg of 3-O-methyl-D-glucose). A new model described the kinetics of the two glucose tracers and native glucose with the use of a two-compartment structure for glucose and a one-compartment structure for insulin effects. Insulin sensitivities of distribution/transport, disposal, and EGP were similar (11.5 3.8 vs. 10.4 3.9 vs. 11.1 2.7 102 mlkg1min1 per mU/l; P nonsignificant, ANOVA). When expressed i