Genitourinary Cancer: Renal, Bladder, and Testicular Active Smoking May Negatively Affect Response Rate, Progression-Free Survival, and Overall Survival of Patients With

Disclosures of potential conflicts of interest may be found at the end of this article. Key Words. Active smoking x Metastatic renal cell carcinoma x Outcome x Sunitinib treatment Learning Objectives Describe the association between risk factors for renal cell carcinoma and the outcome of sunitinib treatment for metastatic disease. Explain the impact of active smoking on the outcome of sunitinib-treated metastatic renal cell carcinoma. Discuss obesity, hypertension, and diabetes in relation to the outcomeof sunitinib-treatedmetastatic renal cell carcinoma. Background. Obesity, smoking, hypertension, and diabetes are risk factors forrenal cell carcinomadevelopment.Theirpresence has been associated with a worse outcome in various cancers. We sought to determine their association with outcome of sunitinib treatment in metastatic renal cell carcinoma (mRCC). Methods. An international multicenter retrospective study of sunitinib-treated mRCC patients was performed. Multivariate analyses were performed to determine the association be-tweenoutcome and the pretreatment status of smoking, body mass index, hypertension, diabetes, and other known prog-nostic factors