doi:10.1016/j.ad.2010.03.017 Randomized Double-blind Comparative Study of 8-Methoxypsoralen Bath Plus UV-A

de regı́menes de tratamiento con 8-metoxypsoraleno en baño-PUVA To the editor: Psoralen–UV-A (PUVA) therapy with topical 8- methoxypso-ralen (8-MOP) is a widely used treatment for patients with moderate to severe psoriasis.1,2 The current regimen for bath PUVA involves soaks in a diluted 8-MOP bath followed by UV-A irradiation twice weekly. Bath PUVA has several advantages over oral PUVA as it avoids the adverse effects of oral psoralen administration (gastrointestinal disturbances and the need to use protective eyewear for 24 h after ingestion), produces a more direct psoralen bioavailability to the skin, and requires lower doses of UV-A, resulting in shorter treatment times. Previous studies investigating the characteristics of PUV