This article has not been copyedited a d formatted. The final ver ion may differ from this version.

JPET #77974PIP 1 CANNABINOID CB1 RECEPTOR ANTAGONISTS AS PROMISING NEW MEDICATIONS FOR DRUG DEPENDENCE

Bernard Le Foll
Steven R. Goldberg

January 2004

This article has not been copye ited and formatted. The final version may differ from this version

A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis

Hsiao, WC

[[abstract]]AIM: BPR0912 is a novel and potent peripheral CB1R antagonist. This study investigated t...

OPEN ORIGINAL ARTICLE Role of the endocannabinoid system in obesity induced by

Lh Vähätalo
St Ruohonen
S Mäkelä
L Ailanen
A-m Penttinen
T Stormi
T Kauko
F Piscitelli
C Silvestri
E Savontaus
V Di Marzo

August 2016

OBJECTIVE: Endocannabinoids and neuropeptide Y (NPY) promote energy storage via central and peripher...

JPET # 118737 1

Tung M. Fong
Xiao-ming Guan
Donald J. Marsh
Chun-pyn Shen
D. Sloan Stribling
M. Rosko
Julie Lao
Hong Yu
Yue Feng
Jing C. Xiao
Lex H. T
Van Ploeg
Mark T
Williams K. Hagmann
Linus S. Lin
Thomas J. Lanza
James P. Jewell
Alison M. Strack
D. Euan Macintyre
Lauren P. Shearman

September 2016

Anti-obesity efficacy of a novel cannabinoid-1 receptor inverse agonist MK-0364 in rodent

Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity

Commerford, Susan
He, Xiaohui
Liu, Hong
Seidel, Martin
Jaton, Anne-Lise
Gromada, Jesper
Teixeira, Sandra
Gerber, Sarah
Chen, Alice
Dardik, Beatriz
Chaperon, Frederique
Schwartzkopf, Chad
Nguyen-Tran, Van
Hollenbeck, Thomas
Mcnamara, Peter

January 2011

Pharmacologic antagonism of cannabinoid 1 receptors (CB1 receptors) in the central nervous system (C...

Chemical Synthesis, Pharmacokinetic Properties and Biological Effects of JM-00266, a Putative Non-Brain Penetrant Cannabinoid Receptor 1 Inverse Agonist

Muller, Tania
Demizieux, Laurent
Troy-Fioramonti, Stéphanie
Buch, Chloé
Leemput, Julia
Belloir, Christine
Pais de Barros, Jean-Paul
Jourdan, Tony
Passilly-Degrace, Patricia
Fioramonti, Xavier
Le Bon, Anne-Marie
Vergès, Bruno
Robert, Jean-Michel
Degrace, Pascal

March 2022

International audienceTargeting cannabinoid 1 receptors (CB1R) with peripherally restricted antagoni...

Chemical Synthesis, Pharmacokinetic Properties and Biological Effects of JM-00266, a Putative Non-Brain Penetrant Cannabinoid Receptor 1 Inverse Agonist

Muller, Tania
Demizieux, Laurent
Troy-Fioramonti, Stéphanie
Buch, Chloé
Leemput, Julia
Belloir, Christine
Pais de Barros, Jean-Paul
Jourdan, Tony
Passilly-Degrace, Patricia
Fioramonti, Xavier
Le Bon, Anne-Marie
Vergès, Bruno
Robert, Jean-Michel
Degrace, Pascal

March 2022

International audienceTargeting cannabinoid 1 receptors (CB1R) with peripherally restricted antagoni...

Chemical Synthesis, Pharmacokinetic Properties and Biological Effects of JM-00266, a Putative Non-Brain Penetrant Cannabinoid Receptor 1 Inverse Agonist

Muller, Tania
Demizieux, Laurent
Troy-Fioramonti, Stéphanie
Buch, Chloé
Leemput, Julia
Belloir, Christine
Pais de Barros, Jean-Paul
Jourdan, Tony
Passilly-Degrace, Patricia
Fioramonti, X.
Le Bon, Anne-Marie
Vergès, Bruno
Robert, Jean-Michel
Degrace, Pascal

March 2022

International audienceTargeting cannabinoid 1 receptors (CB1R) with peripherally restricted antagoni...

Chemical Synthesis, Pharmacokinetic Properties and Biological Effects of JM-00266, a Putative Non-Brain Penetrant Cannabinoid Receptor 1 Inverse Agonist

Muller, Tania
Demizieux, Laurent
Troy-Fioramonti, Stéphanie
Buch, Chloé
Leemput, Julia
Belloir, Christine
Pais de Barros, Jean-Paul
Jourdan, Tony
Passilly-Degrace, Patricia
Fioramonti, Xavier
Le Bon, Anne-Marie
Vergès, Bruno
Robert, Jean-Michel
Degrace, Pascal

March 2022

International audienceTargeting cannabinoid 1 receptors (CB1R) with peripherally restricted antagoni...

A novel peripheral cannabinoid 1 receptor antagonist, AJ5012, improves metabolic outcomes and suppresses adipose tissue inflammation in obese mice

김기우

January 2019

The overactivity of cannabinoid 1 receptor (CB1R) is associated with obesity and type 2 diabetes. Fi...

The Acyclic CB1R Inverse Agonist Taranabant Mediates Weight Loss by Increasing Energy Expenditure and Decreasing Caloric Intake

Addy, Carol
Wright, Hamish
Van Laere, Koen
Gantz, Ira
Erondu, Ngozi
Musser, Bret J
Lu, Kaifeng
Yuan, Jinyu
Sanabria-Bohórquez, Sandra M
Stoch, Aubrey
Stevens, Cathy
Fong, Tung M
De Lepeleire, Inge
Cilissen, Caroline
Cote, Josee
Rosko, Kim
Gendrano, Isaias N
Nguyen, Allison Martin
Gumbiner, Barry
Rothenberg, Paul
de Hoon, Jan
Bormans, Guy
Depré, Marleen
Eng, Wai-Si
Ravussin, Eric
Klein, Samuel
Blundell, John
Herman, Gary A
Burns, H Donald
Hargreaves, Richard J
Wagner, John
Gottesdiener, Keith
Amatruda, John M
Heymsfield, Steven B

January 2008

Cannabinoid 1 receptor (CB1R) inverse agonists are emerging as a potential obesity therapy. However,...

Taranabant Cuts the Fat: New Hope for Cannabinoid-Based Obesity Therapies?

Kirkham, Tim C.

January 2008

Endocannabinoid/cannabinoid receptor signaling acts centrally and peripherally to govern appetite an...

Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice.

LoVerme, Jesse
Duranti, Andrea
Tontini, Andrea
Spadoni, Gilberto
Mor, Marco
Rivara, Silvia
Stella, Nephi
Xu, Cong
Tarzia, Giorgio
Piomelli, Daniele

February 2009

Cannabinoid CB(1) receptor antagonists reduce body weight in rodents and humans, but their clinical ...

Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

Tam, Joseph
Cinar, Resat
Liu, Jie
Godlewski, Grzegorz
Wesley, Daniel
Jourdan, Tony
Szanda, Gergő
Mukhopadhyay, Bani
Chedester, Lee
Liow, Jeih-San
Innis, Robert B.
Cheng, Kejun
Rice, Kenner C.
Deschamps, Jeffrey R.
Chorvat, Robert J.
McElroy, John F.
Kunos, George

August 2012

SummaryObesity-related leptin resistance manifests in loss of leptin’s ability to reduce appetite an...

Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice

LoVerme, Jesse
Duranti, Andrea
Tontini, Andrea
Spadoni, Gilberto
Mor, Marco
Rivara, Silvia
Stella, Nephi
Xu, Cong
Tarzia, Giorgio
Piomelli, Daniele

February 2009

Cannabinoid CB(1) receptor antagonists reduce body weight in rodents and humans, but their clinical ...

JPET #77974PIP 1 CANNABINOID CB1 RECEPTOR ANTAGONISTS AS PROMISING NEW MEDICATIONS FOR DRUG DEPENDENCE

Bernard Le Foll
Steven R. Goldberg

January 2004

This article has not been copye ited and formatted. The final version may differ from this version

A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis

Hsiao, WC

[[abstract]]AIM: BPR0912 is a novel and potent peripheral CB1R antagonist. This study investigated t...

OPEN ORIGINAL ARTICLE Role of the endocannabinoid system in obesity induced by

Lh Vähätalo
St Ruohonen
S Mäkelä
L Ailanen
A-m Penttinen
T Stormi
T Kauko
F Piscitelli
C Silvestri
E Savontaus
V Di Marzo

August 2016

OBJECTIVE: Endocannabinoids and neuropeptide Y (NPY) promote energy storage via central and peripher...

JPET # 118737 1

Tung M. Fong
Xiao-ming Guan
Donald J. Marsh
Chun-pyn Shen
D. Sloan Stribling
M. Rosko
Julie Lao
Hong Yu
Yue Feng
Jing C. Xiao
Lex H. T
Van Ploeg
Mark T
Williams K. Hagmann
Linus S. Lin
Thomas J. Lanza
James P. Jewell
Alison M. Strack
D. Euan Macintyre
Lauren P. Shearman

September 2016

Anti-obesity efficacy of a novel cannabinoid-1 receptor inverse agonist MK-0364 in rodent

Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity

Commerford, Susan
He, Xiaohui
Liu, Hong
Seidel, Martin
Jaton, Anne-Lise
Gromada, Jesper
Teixeira, Sandra
Gerber, Sarah
Chen, Alice
Dardik, Beatriz
Chaperon, Frederique
Schwartzkopf, Chad
Nguyen-Tran, Van
Hollenbeck, Thomas
Mcnamara, Peter

January 2011

Pharmacologic antagonism of cannabinoid 1 receptors (CB1 receptors) in the central nervous system (C...

Chemical Synthesis, Pharmacokinetic Properties and Biological Effects of JM-00266, a Putative Non-Brain Penetrant Cannabinoid Receptor 1 Inverse Agonist

Muller, Tania
Demizieux, Laurent
Troy-Fioramonti, Stéphanie
Buch, Chloé
Leemput, Julia
Belloir, Christine
Pais de Barros, Jean-Paul
Jourdan, Tony
Passilly-Degrace, Patricia
Fioramonti, Xavier
Le Bon, Anne-Marie
Vergès, Bruno
Robert, Jean-Michel
Degrace, Pascal

March 2022

International audienceTargeting cannabinoid 1 receptors (CB1R) with peripherally restricted antagoni...

Chemical Synthesis, Pharmacokinetic Properties and Biological Effects of JM-00266, a Putative Non-Brain Penetrant Cannabinoid Receptor 1 Inverse Agonist

Muller, Tania
Demizieux, Laurent
Troy-Fioramonti, Stéphanie
Buch, Chloé
Leemput, Julia
Belloir, Christine
Pais de Barros, Jean-Paul
Jourdan, Tony
Passilly-Degrace, Patricia
Fioramonti, Xavier
Le Bon, Anne-Marie
Vergès, Bruno
Robert, Jean-Michel
Degrace, Pascal

March 2022

International audienceTargeting cannabinoid 1 receptors (CB1R) with peripherally restricted antagoni...

Chemical Synthesis, Pharmacokinetic Properties and Biological Effects of JM-00266, a Putative Non-Brain Penetrant Cannabinoid Receptor 1 Inverse Agonist

Muller, Tania
Demizieux, Laurent
Troy-Fioramonti, Stéphanie
Buch, Chloé
Leemput, Julia
Belloir, Christine
Pais de Barros, Jean-Paul
Jourdan, Tony
Passilly-Degrace, Patricia
Fioramonti, X.
Le Bon, Anne-Marie
Vergès, Bruno
Robert, Jean-Michel
Degrace, Pascal

March 2022

International audienceTargeting cannabinoid 1 receptors (CB1R) with peripherally restricted antagoni...

Chemical Synthesis, Pharmacokinetic Properties and Biological Effects of JM-00266, a Putative Non-Brain Penetrant Cannabinoid Receptor 1 Inverse Agonist

Muller, Tania
Demizieux, Laurent
Troy-Fioramonti, Stéphanie
Buch, Chloé
Leemput, Julia
Belloir, Christine
Pais de Barros, Jean-Paul
Jourdan, Tony
Passilly-Degrace, Patricia
Fioramonti, Xavier
Le Bon, Anne-Marie
Vergès, Bruno
Robert, Jean-Michel
Degrace, Pascal

March 2022

International audienceTargeting cannabinoid 1 receptors (CB1R) with peripherally restricted antagoni...

A novel peripheral cannabinoid 1 receptor antagonist, AJ5012, improves metabolic outcomes and suppresses adipose tissue inflammation in obese mice

김기우

January 2019

The overactivity of cannabinoid 1 receptor (CB1R) is associated with obesity and type 2 diabetes. Fi...

The Acyclic CB1R Inverse Agonist Taranabant Mediates Weight Loss by Increasing Energy Expenditure and Decreasing Caloric Intake

Addy, Carol
Wright, Hamish
Van Laere, Koen
Gantz, Ira
Erondu, Ngozi
Musser, Bret J
Lu, Kaifeng
Yuan, Jinyu
Sanabria-Bohórquez, Sandra M
Stoch, Aubrey
Stevens, Cathy
Fong, Tung M
De Lepeleire, Inge
Cilissen, Caroline
Cote, Josee
Rosko, Kim
Gendrano, Isaias N
Nguyen, Allison Martin
Gumbiner, Barry
Rothenberg, Paul
de Hoon, Jan
Bormans, Guy
Depré, Marleen
Eng, Wai-Si
Ravussin, Eric
Klein, Samuel
Blundell, John
Herman, Gary A
Burns, H Donald
Hargreaves, Richard J
Wagner, John
Gottesdiener, Keith
Amatruda, John M
Heymsfield, Steven B

January 2008

Cannabinoid 1 receptor (CB1R) inverse agonists are emerging as a potential obesity therapy. However,...

Taranabant Cuts the Fat: New Hope for Cannabinoid-Based Obesity Therapies?

Kirkham, Tim C.

January 2008

Endocannabinoid/cannabinoid receptor signaling acts centrally and peripherally to govern appetite an...

Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice.

LoVerme, Jesse
Duranti, Andrea
Tontini, Andrea
Spadoni, Gilberto
Mor, Marco
Rivara, Silvia
Stella, Nephi
Xu, Cong
Tarzia, Giorgio
Piomelli, Daniele

February 2009

Cannabinoid CB(1) receptor antagonists reduce body weight in rodents and humans, but their clinical ...

Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

Tam, Joseph
Cinar, Resat
Liu, Jie
Godlewski, Grzegorz
Wesley, Daniel
Jourdan, Tony
Szanda, Gergő
Mukhopadhyay, Bani
Chedester, Lee
Liow, Jeih-San
Innis, Robert B.
Cheng, Kejun
Rice, Kenner C.
Deschamps, Jeffrey R.
Chorvat, Robert J.
McElroy, John F.
Kunos, George

August 2012

SummaryObesity-related leptin resistance manifests in loss of leptin’s ability to reduce appetite an...

Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice

LoVerme, Jesse
Duranti, Andrea
Tontini, Andrea
Spadoni, Gilberto
Mor, Marco
Rivara, Silvia
Stella, Nephi
Xu, Cong
Tarzia, Giorgio
Piomelli, Daniele

February 2009

Cannabinoid CB(1) receptor antagonists reduce body weight in rodents and humans, but their clinical ...

JPET #77974PIP 1 CANNABINOID CB1 RECEPTOR ANTAGONISTS AS PROMISING NEW MEDICATIONS FOR DRUG DEPENDENCE

Bernard Le Foll
Steven R. Goldberg

January 2004

This article has not been copye ited and formatted. The final version may differ from this version

A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis

Hsiao, WC

[[abstract]]AIM: BPR0912 is a novel and potent peripheral CB1R antagonist. This study investigated t...

OPEN ORIGINAL ARTICLE Role of the endocannabinoid system in obesity induced by

Lh Vähätalo
St Ruohonen
S Mäkelä
L Ailanen
A-m Penttinen
T Stormi
T Kauko
F Piscitelli
C Silvestri
E Savontaus
V Di Marzo

August 2016

OBJECTIVE: Endocannabinoids and neuropeptide Y (NPY) promote energy storage via central and peripher...

This article has not been copyedited a d formatted. The final ver ion may differ from this version.

Abstract

Extracted data

This article has not been copyedited a d formatted. The final ver ion may differ from this version.

Abstract

Extracted data

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