Dose-dependent inhibition by three organic calcium channel an-tagonists, D-600, nisoldipine and diltiazem, of the inward calcium current (i) and the delayed, outward potassium current (K) in single frog atrial cells was examined using a voltage clamp technique. At holding potentials of-60 mV, low concentrations of these antagonists produced considerable inhibition of i with-out significant alterations in K, suggesting that K in single frog atrial cells is not a calcium-activated K conductance. Higher concentrations of each of these antagonists, however, inhibited 1K#{149}The estimated K values for inhibition of i and K, respectively, were 3.7 x 1 0- M and 8.2 x 1 0 M for D-600, 1.6 x 1 0 M and 1.6 x 10 M for nisoldipine and 4.4 x 10...
Antidepressants inhibit many membrane receptors and ionic channels, including the L-type calcium cha...
A chemically heterogeneous group of compounds, the Ca channel antagonists, which includes verapamil,...
Nifedipine antagonizes current flow through both cardiovascular L-type Ca2+ channels and voltage-ga...
The chief site of action of the calcium antagonist drugs is the slow calcium channel in two tissues:...
Voltage-sensitive calcium channels (L-type) mediate the entry of extracellular calcium into smooth m...
Drugs of several chemical families have been identified as calcium antagonists. This article examine...
The inhibitory effect of calcium antagonists has been studied on the calcium signal and on contracti...
The currents through voltage-activated calcium channels in heart cell membranes are suppressed by di...
The relationship between extracellular calcium concentration and the chronotropic effect of prenylam...
Thecurrents through voltage-activated calcium channels in heart cell membranes are suppressed by dih...
The effects of SR 33557 on isolated cardiovascular preparations were compared to those of nifedipine...
In order to get more insight into the utilization of calcium in the mammalian heart and the influenc...
Ten known calcium channel blockers were studied for inhibition of K-induced Ca uptake into rabbit a...
The activities of a series of calcium antagonists including nife-dipine, verapamil, diltiazem and se...
The aim of the study was to examine the use of a repolarizing calcium dependent potassium current K...
Antidepressants inhibit many membrane receptors and ionic channels, including the L-type calcium cha...
A chemically heterogeneous group of compounds, the Ca channel antagonists, which includes verapamil,...
Nifedipine antagonizes current flow through both cardiovascular L-type Ca2+ channels and voltage-ga...
The chief site of action of the calcium antagonist drugs is the slow calcium channel in two tissues:...
Voltage-sensitive calcium channels (L-type) mediate the entry of extracellular calcium into smooth m...
Drugs of several chemical families have been identified as calcium antagonists. This article examine...
The inhibitory effect of calcium antagonists has been studied on the calcium signal and on contracti...
The currents through voltage-activated calcium channels in heart cell membranes are suppressed by di...
The relationship between extracellular calcium concentration and the chronotropic effect of prenylam...
Thecurrents through voltage-activated calcium channels in heart cell membranes are suppressed by dih...
The effects of SR 33557 on isolated cardiovascular preparations were compared to those of nifedipine...
In order to get more insight into the utilization of calcium in the mammalian heart and the influenc...
Ten known calcium channel blockers were studied for inhibition of K-induced Ca uptake into rabbit a...
The activities of a series of calcium antagonists including nife-dipine, verapamil, diltiazem and se...
The aim of the study was to examine the use of a repolarizing calcium dependent potassium current K...
Antidepressants inhibit many membrane receptors and ionic channels, including the L-type calcium cha...
A chemically heterogeneous group of compounds, the Ca channel antagonists, which includes verapamil,...
Nifedipine antagonizes current flow through both cardiovascular L-type Ca2+ channels and voltage-ga...