To characterize age-related changes in b-adrenergic respon-siveness and to test the hypothesis that an increase in the effects of adenosine contribute to impaired b-adrenergic re-sponsiveness, Fischer 344 rat right atria (RA), left atria (LA), and left ventricular trabeculae carnae were exposed to the b-recep-tor agonist isoproterenol (ISO), followed by four doses of the selective adenosine A1 receptor agonist cyclopentyladenosine (CPA). Spontaneous contractile rates of adult RA were inhibited more than senescent RA by CPA. Contractility (1dF/dt) of adult LA was reduced more than senescent LA by CPA. Left trabec-ulae carnae tissue responded weakly to CPA, but senescent tissue was less responsive than adult tissue. Senescent atrial A1 recept...
The antiadrenergic action of adenosine was examined in open- and closed-chest preparations of anesth...
Consecutive treatment of adult rat heart with isoproterenol and adenosine (Iso/Aden), known to conse...
Using the Fischer 344 rat model and blood vessel ring segments in vitro, age-related changes in vasc...
Interstitial levels and release of adenosine have been shown to be greater for aged adult hearts com...
The contractile response of the aged adult heart to beta-adrenergic stimulation is known to be reduc...
Because adenosine has an antiadrenergic action in the heart, young (3-4 mo) and aged (18-20 mo) adul...
The purpose of this study was to determine whether aged myocardium exhibits decreased responsiveness...
Previously published reports from this laboratory have shown that the antiadrenergic effect of adeno...
Basal, 5'-guanylimidodiphosphate, GTP-, NaF-, forskolin-, D,L-isoproterenol-, glucagon- and secretin...
1. The vasodilator effects of adenosine receptor agonists, isoprenaline and histamine were examined ...
Adenosine (Ado), a naturally occurring autacoid, exerts cardioprotective effects against myocardial ...
Previous studies have shown that the inotropic response of the heart to P3-adrenergic stimulation de...
Adenosine levels present in the interstitial fluid and coronary effluent of the aged heart exceed th...
1. The effects of aging on the responsiveness of the isolated pacemaker of the rat to the chronotrop...
OBJECTIVE: The contractile response to digitalis and beta adrenoceptor agonists is lower in the sene...
The antiadrenergic action of adenosine was examined in open- and closed-chest preparations of anesth...
Consecutive treatment of adult rat heart with isoproterenol and adenosine (Iso/Aden), known to conse...
Using the Fischer 344 rat model and blood vessel ring segments in vitro, age-related changes in vasc...
Interstitial levels and release of adenosine have been shown to be greater for aged adult hearts com...
The contractile response of the aged adult heart to beta-adrenergic stimulation is known to be reduc...
Because adenosine has an antiadrenergic action in the heart, young (3-4 mo) and aged (18-20 mo) adul...
The purpose of this study was to determine whether aged myocardium exhibits decreased responsiveness...
Previously published reports from this laboratory have shown that the antiadrenergic effect of adeno...
Basal, 5'-guanylimidodiphosphate, GTP-, NaF-, forskolin-, D,L-isoproterenol-, glucagon- and secretin...
1. The vasodilator effects of adenosine receptor agonists, isoprenaline and histamine were examined ...
Adenosine (Ado), a naturally occurring autacoid, exerts cardioprotective effects against myocardial ...
Previous studies have shown that the inotropic response of the heart to P3-adrenergic stimulation de...
Adenosine levels present in the interstitial fluid and coronary effluent of the aged heart exceed th...
1. The effects of aging on the responsiveness of the isolated pacemaker of the rat to the chronotrop...
OBJECTIVE: The contractile response to digitalis and beta adrenoceptor agonists is lower in the sene...
The antiadrenergic action of adenosine was examined in open- and closed-chest preparations of anesth...
Consecutive treatment of adult rat heart with isoproterenol and adenosine (Iso/Aden), known to conse...
Using the Fischer 344 rat model and blood vessel ring segments in vitro, age-related changes in vasc...