Early events governing memory CD81 T-cell differentiation

Understanding the regulation of the CD81 T-cell response and how protective memory cells are generated has been intensely studied. It is now appreciated that a naive CD81 T cell requires at least three signals to mount an effective immune response: (i) TCR triggering, (ii) co-stimulation and (iii) inflammatory cytokines. Only recently have we begun to understand the molecular integration of those signals and how early events regulate the fate decisions of the responding CD81 T cells. This review will discuss the recent findings about both the extracellular and intracellular factors that regulate the destiny of responding CD81 T cells