Add to ORKGWe describe a fully automated assay for determining effec-tive heparin activity in plasma, based on heparin-catalyzed inhibition of Factor Xa (EC 3.4.21.6) by antithrombin Ill (AT Ill). Residual Factor Xa is determined kinetically by the Du Pont aca#{174}discrete clinical analyzer with a chromogenic substrate and is inversely related to heparin activity. Because the test plasma is the sole source of AT Ill, the assay result is dependent on AT Ill activity and reflects effective rather than total heparin activity. The assay range is 20-1200 USP units/L, and the assay shows equivalent sensitivity to stan-dard and low-molecular-mass heparins. Within-run reproduc-ibility (CV) is 1.6 % at 390 units/L. There was no interference from common blood ...
Heparins inhibit the thrombin forming capacity of plasma, i. e., the endogenous thrombin potential (...
We describe assays for functional antithrombin III (AT III) and plasminogen in plasma with the Du Po...
Low molecular weight heparins (LMWH’s) are used to prevent and treat thrombosis. Tests for monitorin...
Using the chromogenic substrate S-2222, we have optimized and automated an amidolytic assay for hepa...
It is discussed why the current USP unit of heparin anticoagulant activity necessarily will render i...
Spectrophotometric heparin assays which are based on the catalytic effect of heparin on either the i...
(Figure 2) or normal plasma (Figure 3) seems to eliminate this deviation. The Heptest facilitates ea...
The activi ty of a heparin preparation is most easi ly determined relat ive to a heparin standard. I...
Heparins, unfractionated or low molecular weight, are permanently in the spotlight of both clinical ...
unfractionated (UF) and low molecular weight (tMW) heparins have been measured in human plasma and w...
Heparins inhibit the thrombin forming capacity of plasma, i. e., the endogenous thrombin potential (...
A new sensitive chromogenic heparin assay is developed, which is well suited for clinical use. For t...
Fluorogenic assays have many potential advantages over traditional clot-based and chromogenic assays...
Abstract. Three automated spectrophotometric heparin assays were inyestigated. The day-to-day reprod...
The applicability was investigated of automated spectrophotometric heparin assays and three clotting...
Heparins inhibit the thrombin forming capacity of plasma, i. e., the endogenous thrombin potential (...
We describe assays for functional antithrombin III (AT III) and plasminogen in plasma with the Du Po...
Low molecular weight heparins (LMWH’s) are used to prevent and treat thrombosis. Tests for monitorin...
Using the chromogenic substrate S-2222, we have optimized and automated an amidolytic assay for hepa...
It is discussed why the current USP unit of heparin anticoagulant activity necessarily will render i...
Spectrophotometric heparin assays which are based on the catalytic effect of heparin on either the i...
(Figure 2) or normal plasma (Figure 3) seems to eliminate this deviation. The Heptest facilitates ea...
The activi ty of a heparin preparation is most easi ly determined relat ive to a heparin standard. I...
Heparins, unfractionated or low molecular weight, are permanently in the spotlight of both clinical ...
unfractionated (UF) and low molecular weight (tMW) heparins have been measured in human plasma and w...
Heparins inhibit the thrombin forming capacity of plasma, i. e., the endogenous thrombin potential (...
A new sensitive chromogenic heparin assay is developed, which is well suited for clinical use. For t...
Fluorogenic assays have many potential advantages over traditional clot-based and chromogenic assays...
Abstract. Three automated spectrophotometric heparin assays were inyestigated. The day-to-day reprod...
The applicability was investigated of automated spectrophotometric heparin assays and three clotting...
Heparins inhibit the thrombin forming capacity of plasma, i. e., the endogenous thrombin potential (...
We describe assays for functional antithrombin III (AT III) and plasminogen in plasma with the Du Po...
Low molecular weight heparins (LMWH’s) are used to prevent and treat thrombosis. Tests for monitorin...