On the structural organization of the transcriptional unit in animal chromosomes. Co/d Spring Harbor

Three levels of genome organization i eukary-otes are considered in this paper: (1) the structure" of the transcriptional unit (or transcripton); (2) the arrangement of proteins along unfolded chromo-somal DNA in chromatin; and (3) the mode of DNA packing in the chromatin. The Structure of Transcripton The model. Briefly, according to a model proposed previously (Georgiev, 1969) and slightly modified now (Fig. 1), the transcripton consists of a rather small structural zone containing one or a few structural genes and a large acceptor zone, which does not carry structural information but contains the acceptor sites interacting with struc-tural and regulatory proteins of the chromosome