Structural studies of oligosacchande chains of immunoglob-ulin G (lgG) in serum have revealed a specific galactosylation deficiency associated with rheumatoid arthritis (RA). Using a two-site Iectin-immunofluorometric assay, I studied the inter-action of IgG with immobilized lectins. Compared with control lgG, IgG purified from RA patients ’ sera bound up to 40-fold more strongly to immobilized Bandeiraea simplicifolia agglu-tinin II, a Iectin that specifically binds agalacto forms of other glycoproteins. However, inhibition studies and treatment of I9G with glycosidase suggested that only a minor part of this binding was mediated by agalacto oligosaccharides of IgG. Furthermore, these IgG samples bound even more inten-sively to some other ...
Serum IgG from patients with both adult- and juvenile-onset rheumatoid arthritis when compared to ag...
The clinical significance of the percentage agalactosyl IgG oligosaccharides [%G(O)] was investigate...
In addition to the redundancy of the receptors for the Fc portion of immunoglobulins, glycans result...
The goal of this study was to investigate the glycosylation profile of native immunoglobulin (Ig)G p...
In patients with rheumatoid arthritis (RA) a decrease in the terminal galactose content of N-linked ...
A solid phase radioimmunoassay was set up for direct measurement of the binding capacity of h...
It has been postulated that agalactosyl immunoglobulin G (IgG) self-associates to form pathological ...
The N-glycosylation of human immunoglobulins, especially IgGs, plays a critical role in determining ...
Evidence indicating an important role for antigen in the provocation of autoimmune responses is pres...
Previous reports have shown that deficient galactosylation of serum IgG occurs in patients with rheu...
Background: Serum protein glycosylation is an area of investigation in inflammatory arthritic disord...
Antibodies are known to have an important role in the development of rheumatoid arthritis (RA), one ...
Immunoglobulin G (IgG) is glycosylated in both the Fc and the Fab regions of the protein with a hete...
Objective. To examine the association between aberrant IgG galactosylation and disease parameters in...
Alterations in the glycosylation of human IgG have been shown to occur in rheumatoid arthritis (RA)....
Serum IgG from patients with both adult- and juvenile-onset rheumatoid arthritis when compared to ag...
The clinical significance of the percentage agalactosyl IgG oligosaccharides [%G(O)] was investigate...
In addition to the redundancy of the receptors for the Fc portion of immunoglobulins, glycans result...
The goal of this study was to investigate the glycosylation profile of native immunoglobulin (Ig)G p...
In patients with rheumatoid arthritis (RA) a decrease in the terminal galactose content of N-linked ...
A solid phase radioimmunoassay was set up for direct measurement of the binding capacity of h...
It has been postulated that agalactosyl immunoglobulin G (IgG) self-associates to form pathological ...
The N-glycosylation of human immunoglobulins, especially IgGs, plays a critical role in determining ...
Evidence indicating an important role for antigen in the provocation of autoimmune responses is pres...
Previous reports have shown that deficient galactosylation of serum IgG occurs in patients with rheu...
Background: Serum protein glycosylation is an area of investigation in inflammatory arthritic disord...
Antibodies are known to have an important role in the development of rheumatoid arthritis (RA), one ...
Immunoglobulin G (IgG) is glycosylated in both the Fc and the Fab regions of the protein with a hete...
Objective. To examine the association between aberrant IgG galactosylation and disease parameters in...
Alterations in the glycosylation of human IgG have been shown to occur in rheumatoid arthritis (RA)....
Serum IgG from patients with both adult- and juvenile-onset rheumatoid arthritis when compared to ag...
The clinical significance of the percentage agalactosyl IgG oligosaccharides [%G(O)] was investigate...
In addition to the redundancy of the receptors for the Fc portion of immunoglobulins, glycans result...