Calprotectin (CP) is a transition metal-chelating antimicrobial protein of the calcium-binding S100 family that is produced and released by neutrophils. It inhibits the growth of various pathogenic microorganisms by sequestering the transition metal ions manganese and zinc. In this work, we investigate the manganese-binding properties of calprotectin. We demonstrate that the unusual His4 motif (site 2) formed at the S100A8/S100A9 dimer interface is the site of high-affinity Mn(II) coordination. We identify a low-temperature Mn(II) spectroscopic signal for this site consistent with an octahedral Mn(II) coordination sphere with simulated zero-field splitting parameters D = 270 MHz and E/D = 0.33 (E = 81 MHz). This analysis, combined with stud...
Calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/MRP-14 oligomer) is a host-defense protein that sequ...
Human calprotectin (CP, S100A8/S100A9 oligomer) is a metal-sequestering host-defense protein that pr...
Calprotectin (CP) is an antimicrobial protein produced and released by neutrophils that inhibits the...
Calprotectin (CP) is a transition metal-chelating antimicrobial protein of the calcium-binding S100 ...
Calprotectin (CP) is a transition metal-chelating antimicrobial protein of the calcium-binding S100 ...
Manganese is an essential metal ion that bacterial pathogens need to acquire from the vertebrate hos...
The antimicrobial protein calprotectin (CP), a hetero-oligomer of the S100 family members S100A8 and...
Human calprotectin (CP) is an antimicrobial protein that coordinates Mn(II) with high affinity in a ...
The antimicrobial protein calprotectin (CP), a hetero-oligomer of the S100 family members S100A8 and...
The antimicrobial protein calprotectin (CP), a hetero-oligomer of the S100 family members S100A8 and...
Thesis: Ph. D. in Biological Chemistry, Massachusetts Institute of Technology, Department of Chemist...
Human calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/MRP-14 oligomer) is an abundant host-defense p...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2017.Vita. Cataloged...
Calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/14 oligomer, calgranulins A and B) is a protein comp...
Human calprotectin (CP) is an antimicrobial protein that coordinates Mn(II) with high affinity in a...
Calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/MRP-14 oligomer) is a host-defense protein that sequ...
Human calprotectin (CP, S100A8/S100A9 oligomer) is a metal-sequestering host-defense protein that pr...
Calprotectin (CP) is an antimicrobial protein produced and released by neutrophils that inhibits the...
Calprotectin (CP) is a transition metal-chelating antimicrobial protein of the calcium-binding S100 ...
Calprotectin (CP) is a transition metal-chelating antimicrobial protein of the calcium-binding S100 ...
Manganese is an essential metal ion that bacterial pathogens need to acquire from the vertebrate hos...
The antimicrobial protein calprotectin (CP), a hetero-oligomer of the S100 family members S100A8 and...
Human calprotectin (CP) is an antimicrobial protein that coordinates Mn(II) with high affinity in a ...
The antimicrobial protein calprotectin (CP), a hetero-oligomer of the S100 family members S100A8 and...
The antimicrobial protein calprotectin (CP), a hetero-oligomer of the S100 family members S100A8 and...
Thesis: Ph. D. in Biological Chemistry, Massachusetts Institute of Technology, Department of Chemist...
Human calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/MRP-14 oligomer) is an abundant host-defense p...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2017.Vita. Cataloged...
Calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/14 oligomer, calgranulins A and B) is a protein comp...
Human calprotectin (CP) is an antimicrobial protein that coordinates Mn(II) with high affinity in a...
Calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/MRP-14 oligomer) is a host-defense protein that sequ...
Human calprotectin (CP, S100A8/S100A9 oligomer) is a metal-sequestering host-defense protein that pr...
Calprotectin (CP) is an antimicrobial protein produced and released by neutrophils that inhibits the...