Synthesis and Characterization of PEG–PCL–PEG Triblock

ABSTRACT: Triblock copolymers of monomethoxy poly(ethylene glycol) (mPEG) and e-caprolactone (CL) were prepared with varying lengths of poly(e-caprolac-tone) (PCL) compositions and a fixed length of mPEG segment. The molecular characteristics of triblock copoly-mers were characterized by 1H NMR, gel permeation chromatography (GPC), Fourier transform infrared spec-troscopy (FT-IR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). These amphiphilic linear copolymers based on PCL hydrophobic chain and hydro-philic mPEG ending, which can self-assemble into nano-scopic micelles with their hydrophobic cores, encapsulated doxorubicin (DOX) in an aqueous solution. The particle size of prepared micelles was around 40– 92 nm. The DOX loading content and DOX loading effi