Abstract: Insulin sensitivity and insulin secretion are reciprocally related such that insulin resistance is adapted by increased insulin secretion to maintain normal glucose and lipid homeostasis. The relation between insulin sensitivity and secretion is curvilinear and mathematically best described as a hyperbolic relation. Several potential mediators have been suggested to be signals for the beta cells to respond to insulin resistance such as glucose, free fatty acids, autonomic nerves, fat-derived hormones and the gut hormone glucagon-like peptide-1 (GLP-1). Failure of these signals or of the pancreatic beta cells to adequately adapt insulin secretion in relation to insulin sensitivity results in inappropriate insulin levels, impaired g...
Type 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests when insu...
Type 2 diabetes is associated with insulin resistance and reduced insulin secretion, which results i...
ABSTRACT: The therapeutic goals in patients with type 2 diabetes mellitus and the mechanisms of insu...
Diabetes is a disease, characterized by the failure of the body to make or use insulin, resulting in...
Type 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests when insu...
Physiologic insulin secretion consists of an oscillating pattern of secretion followed by distinct t...
One major risk factor of type 2 diabetes is the impairment of glucose-induced insulin secretion whic...
Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic b-cell dysfunction, the ...
Insulin, since its discovery in the 19th century until our days, has been considered as one of the b...
Context: Insulin resistance impacts virtually all tissues, incluDing pancreatic cells. Individuals w...
peer reviewedDefects in pancreatic islet beta-cell function play a major role in the development of ...
It has long been assumed that type 2 diabetes is caused by the combined effects of insulin resistanc...
OBJECTIVEdWe investigated the effect of early-phase insulin secretion on the incidence of type 2 dia...
OBJECTIVE-Recent work has shown that insulin stimulates its own secretion in insulin-sensitive human...
Although it is well established that type 2 diabetes (T2D) is generally due to the progressive loss ...
Type 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests when insu...
Type 2 diabetes is associated with insulin resistance and reduced insulin secretion, which results i...
ABSTRACT: The therapeutic goals in patients with type 2 diabetes mellitus and the mechanisms of insu...
Diabetes is a disease, characterized by the failure of the body to make or use insulin, resulting in...
Type 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests when insu...
Physiologic insulin secretion consists of an oscillating pattern of secretion followed by distinct t...
One major risk factor of type 2 diabetes is the impairment of glucose-induced insulin secretion whic...
Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic b-cell dysfunction, the ...
Insulin, since its discovery in the 19th century until our days, has been considered as one of the b...
Context: Insulin resistance impacts virtually all tissues, incluDing pancreatic cells. Individuals w...
peer reviewedDefects in pancreatic islet beta-cell function play a major role in the development of ...
It has long been assumed that type 2 diabetes is caused by the combined effects of insulin resistanc...
OBJECTIVEdWe investigated the effect of early-phase insulin secretion on the incidence of type 2 dia...
OBJECTIVE-Recent work has shown that insulin stimulates its own secretion in insulin-sensitive human...
Although it is well established that type 2 diabetes (T2D) is generally due to the progressive loss ...
Type 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests when insu...
Type 2 diabetes is associated with insulin resistance and reduced insulin secretion, which results i...
ABSTRACT: The therapeutic goals in patients with type 2 diabetes mellitus and the mechanisms of insu...