AGT M235T and ACE ID polymorphisms and exercise blood pressure in the HERITAGE Family Study

chard. AGT M235T and ACE ID polymorphisms and exercise blood pressure in the HERITAGE Family Study. Am J Physiol Heart Circ Physiol 279: H368–H374, 2000.—We investigated the association between angiotensinogen (AGT) and angioten-sin-converting enzyme (ACE) gene polymorphisms and exercise training responses of resting and exercise blood pressure (BP). BP at rest and during submaximal (50 watts) and maximal exercise tests was measured before and after 20 wk of endur-ance training in 476 sedentary normotensive Caucasian sub-jects from 99 families. AGT M235T and ACE insertion/deletion polymorphisms were typed with PCR-based methods. Men car-rying the AGT MM and MT genotypes showed 3.7 6 0.6 and 3.2 6 0.5 (SE) mmHg reductions, respectively, in diastolic BP at 50 watts (DBP50), whereas, in the TT homozygotes, the de-crease was 0.4 6 1.0 mmHg (P 5 0.016 for trend, adjusted fo