2 0 2 EDITORIALS Annals of Internal Medicine Immunosuppressive Drugs in Rheumatoid Arthritis

used more and more in the treatment ot rheumatoid arthritis. Its potential role has been recognized by a committee of the American Rheumatism Association which is conducting a well-controlled multiclinic study of cyclophosphamide in this disease. The immunosuppressive drugs that have been used in the treatment of rheumatoid arthritis are nitrogen mustard (1-3), aza-thioprine (4-9), 6-mercaptopurine (9-11), chlorambucil (12-14), cyclophosphamide (15), and methotrexate (16). Recently, Mason and his colleagues (4) of the London Hospital published a pre-liminary communication on a double-blin