Seroprevalence of West Nile Virus specific IgG and IgM antibodies in North-Western and Western provinces of Zambia.

Background: West Nile Virus (WNV) infection has been reported worldwide, including in Africa but its existence in Zam-bia is unknown. Symptoms for the virus include headache, myalgia, arthralgia and rash. Objectives: This study aimed to determine the seroprevalence of WNV and its correlates. Methods: A cross sectional study was conducted in North-Western and Western provinces of Zambia. Samples were subjected to IgG and IgM antibodies testing against WNV. Logistic regression analyses were conducted to determine mag-nitudes of association. Results: A total of 3,625 of persons participated in the survey out of which 10.3 % had WNV infection. Farmers were 20 % (AOR=0.80; 95 % CI [0.64, 0.99]) less likely to have infection compared to students. Meanwhile participants who lived in grass roofed houses were 2.97 (AOR=2.97; 95 % CI [1.81, 4.88]) times more likely to be infected than those who lived in asbestos roofed houses. IRS was associated with reduced risk of infection (AOR=0.81; 95 % CI [0.69, 0.94]). Travelling to Angola was associated with the infection [AOR=1.40; 95 % CI [1.09, 1.81]. Conclusion: Spraying houses with insecticide residual spray would minimize mosquito-man contact. Furthermore, surveil