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The advances of interventional cardiology have been achieved by new device develop-ment, finding appropriate drug regimes, and understanding of pathomechanism. Drug-eluting stents (DES) implantation with dual anti-platelet therapy reduced re-vascularization without increasing mortality or myocardial infarction compared with bare-metal stenting. However, late-term stent thrombosis (ST) and restenosis limited its value and raised the safety concern. Main mechanisms of this phenomenon are im-paired endothelialization and hypersensitivity reaction with polymer. The second gen-eration DES further improved safety and/or efficacy by using thinner stent strut and biocompatible polymer. Recently, new concept DES with biodegradable polymer, poly-mer-free and bioabsorbable scaffold are under investigation in the quest to minimize the risk of ST. Key Words: Drug-eluting stents; Coronary thrombosis; Blood platelets This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Licens