A JOURNAL OF NEUROLOGY SCIENTIFIC COMMENTARY

networks in epilepsy Memory is one of the core cognitive abilities that shapes our sense of self-identity and we strive to maintain and improve our memory function throughout our lives. Memory impairments are a key component of a number of neurological and psychiatric diseases, and represent a large part of the disease burden in many patients. The hippocampus has been central to the study of human memory, having been implicated in episodic and long-term memory, novelty detection, sleep-dependent memory con-solidation, the ability to imagine the future, as well as spatial navigation and the binding of temporally and spatially distributed representations (Bartsch, 2012). What’s more, the hippocampus is also involved in neurobiological mechanisms beyond memory for-mation such as the regulation of emotion, fear, anxiety, and stress. Notably, the hippocampus displays a particular vulnerabilit