LEVEL:ni. Strong and Specific interactions of Some Incapa~~~~ting

. D ~ 5~~In recent years the anti—psychotic and other neurological effects of the tranquilizing phenothiazines have been well described. As a class, they serve a variety of needs and their potent tranquil— izing activities render them exceeding’y valuable in the treatment of mental disorders. Widespread research has provided an excellent data base for further neuroleptic studies. At Edgewood, such studies have been directed toward the discovery of new and potent neurological incapacitating agents to temporarily render soldiers mentally incapahie of waging warfare. Several phenothiazines such as 2—nitro—10-g3 — 14—,_. (2—hydroxyethyl)—1—p iperazinylj propyl ~ phenothiazine dimaleate (I)were found to be sufficiently potent to produce these effects. Their ~~ ~ incapacitating activities are described elsewhere (2)~ C- ’ In searching for new biologically active compounds an under— LU standing of the mechanism of biological action is most important, for such information can lead directly to the design of drugs and agents ~~ ~ L.L ~ of superior activity. Furthermore, a knowledge of in vivo inter—actions of such compounds with tissues is imperative when considering them for human use. Such is the case for the studies described herei