The Effect of Bridelia ferruginea and Senna alata on Plasma Glucose Concentration in Normoglycemic and Glucose Induced Hyperglycemic Rats

A total of 30 female albino rats were used in this study. The plasma glucose levels in these subjects were estimated after administration of methanol extracts of Bridelia ferruginea and Senna alata. The mean ages of the rats were 8 weeks old and mean weights were 165g. Phytochemical screening of the methanol bark extract of Bridelia ferruginea and methanol leaves extract of Senna alata revealed the presence of tannins, polyphenols, steroids, triterpenes, and alkaloids. Methanol extract of Bridelia ferruginea bark achieved statistical significant difference in the normoglycemic rats and glucose induced hyperglycemic rats (P<0.05). There was no statistical significant difference observed in the control rats (P<0.05). However, Senna alata did not achieve any significant difference statistically in normoglycemic, hyperglycemic and control rats (P>0.05). The effect of Bridelia ferruginea and Senna alata methanol extracts on plasma glucose concentration in normoglycemic and glucose induce hyperglycemic rats is therefore discussed