RE: Plasma Phospholipid Fatty Acids and Prostate Cancer Risk in the SELECT

Recent findings reported by Brasky et al. (1) contradict the expectation that high consumption of n-3 polyunsaturated fatty acids (PUFAs) would reduce the risk of prostate cancer. A generally held view is that omega-6 fatty acid (n-6FA) promotes tumor development because arachidonic acid–derived oxylipins have proinflamma-tory and proangiogenic effects. n-3 fatty acids (n-3FAs) are thought to protect from cancer because they are substrates for the same metabolic enzymes used by n-6FA, thus suppressing the formation of the protumorigenic n-6FA–derived oxylipins. Furthermore, n-3FA–derived oxylipin