Comparative Study of Ezetimibe and Atorvastatin Alone and in Combination on Lipid Profile in Rats

Introduction: Coronary heart disease and hyperlipidemia is a global problem in today’s world. A large number of people suffer from hyperten-sion, atherosclerosis and all these has strong association with the hyperlipidemia. There are many drugs for the treatment of hyperlipidemia, but statins are most commonly used. But, with high dose of statins, the side effect is also there which restricts its use in high dose. Ezetimibe is a comparatively new drug for the treatment of hyperlipidemia having lesser adverse effect as compared to statin. This study has been planned to find out the comparative efficacy of Ezetimibe and Atorvastatin alone and in combination on the lipid profile in rats. Methodology: This study wa