Add to ORKGPolypeptide libraries cast a broad net for defining enzyme and binding protein specificities. In addition to uncovering rules for molecular recognition, the binding preferences and functional group tolerances from such libraries can reveal mechanisms underlying biochemical and cellular processes. Ligands obtained from protein libraries can also provide pharmaceutical lead compounds and even reagents to further explore cell biology. Here, we review selected recent examples of protein libraries demonstrating these principles. In particular, we focus on combinatorial libraries composed of randomized peptides or variations of a single protein. The characteristics of various techniques for library constructions and screening are also briefly sur...
In the continuing effort to find small molecules that alter protein function and ultimately might le...
Global functional genome and proteome research aims at a complete description of the network of prot...
High-diversity genetically-encoded combinatorial libraries (108−1013 members) are a rich source of p...
Polypeptide libraries cast a broad net for defining enzyme and binding protein specificities. In add...
SummaryNew ligands for a variety of biological targets can be selected from biological or synthetic ...
New ligands for a variety of biological targets can be selected from biological or synthetic combina...
Powerful strategies for screening protein libraries further strengthen the arguments for applying ‘i...
Combinatorial chemistry and biology have become popular methods for the identification of bio-active...
A review. The technique of combinatorial peptide ligand libraries (CPLL), for capturing and amplify...
Over the past decade, several methods have been developed for the construction of DNA-encoded peptid...
Protein design critically tests our understanding of principles that specify the protein folded stat...
The construction of new and increasingly diverse libraries, as well as the implementation of more po...
Screening phage-displayed combinatorial peptide library is an effective approach for discovery of pe...
Combinatorial screening methodology has been employed to select new affinity specific ligands to bil...
Peptide nucleic acid (PNA)-encoded chemical libraries along with DNA-encoded libraries have provided...
In the continuing effort to find small molecules that alter protein function and ultimately might le...
Global functional genome and proteome research aims at a complete description of the network of prot...
High-diversity genetically-encoded combinatorial libraries (108−1013 members) are a rich source of p...
Polypeptide libraries cast a broad net for defining enzyme and binding protein specificities. In add...
SummaryNew ligands for a variety of biological targets can be selected from biological or synthetic ...
New ligands for a variety of biological targets can be selected from biological or synthetic combina...
Powerful strategies for screening protein libraries further strengthen the arguments for applying ‘i...
Combinatorial chemistry and biology have become popular methods for the identification of bio-active...
A review. The technique of combinatorial peptide ligand libraries (CPLL), for capturing and amplify...
Over the past decade, several methods have been developed for the construction of DNA-encoded peptid...
Protein design critically tests our understanding of principles that specify the protein folded stat...
The construction of new and increasingly diverse libraries, as well as the implementation of more po...
Screening phage-displayed combinatorial peptide library is an effective approach for discovery of pe...
Combinatorial screening methodology has been employed to select new affinity specific ligands to bil...
Peptide nucleic acid (PNA)-encoded chemical libraries along with DNA-encoded libraries have provided...
In the continuing effort to find small molecules that alter protein function and ultimately might le...
Global functional genome and proteome research aims at a complete description of the network of prot...
High-diversity genetically-encoded combinatorial libraries (108−1013 members) are a rich source of p...