Construction of an Asymmetric Quaternary Carbon Center via Allylation of Hydrazones

There has been great interest in developing methods for asymmetric nucleophilic allylic addition of organometallic reagents to imine derivatives.1 The resulting homoallylic amines are valuable compounds which are used as building blocks for preparing biologically active molecules and pharmaceutically important compounds.2 However, due to the low reactivity of C=N bonds to nucleophiles, strong organometallic reagents are required, causing deprotonation of enolizable imines instead of addition. Among the various allylic metal reagents, allylindium reagents are suitable for allylation of imines. Allylindium reagents have several ad-vantages including low basicity, selective nucleophilicity, low toxicity, and stability to moisture and air.3 Asymmetric indium-mediated allylation of imine deriva-tives bearing a chiral auxiliary is a reliable strategy for th