Endophenotyping schizophrenia

The articles that appear in this issue offer a frame-work of insights about the neuroanatomy of schizo-phrenia from three learned and creative perspectives. All three articles advance our understanding of schizo-phrenia from a single locus/specific "lesion " model to more advanced perspectives of neural circuit dysfunc-tion models. Goldman-Rakic and Selemon review their own and others ' work on structure-activity relation-ships of the frontal cortex and related working mem-ory dysfunction. This important but sometimes cloudy and complex area is illuminated by their highly spe-cific, informative research. Jones focuses on thalamic abnormalities hypothetically linked to abnormal oscil-lations in large arrays of cortical and thalamic neurons