Infectious Burden and Carotid Plaque Thickness The Northern Manhattan Study

Background and Purpose—The overall burden of prior infections may contribute to atherosclerosis and stroke risk. We hypothesized that serological evidence of common infections would be associated with carotid plaque thickness in a multiethnic cohort. Methods—Antibody titers to 5 common infectious microorganisms (ie, Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, and herpesvirus 1 and 2) were measured among stroke-free community participants and a weighted index of infectious burden was calculated based on Cox models previously derived for the association of each infection with stroke risk. High-resolution carotid duplex Doppler studies were used to assess maximum carotid plaque thickness. Weighted least squares regression was used to measure the association between infectious burden and maximum carotid plaque thickness after adjusting for other risk factors. Results—Serological results for all 5 infectious organisms were available in 861 participants with maximum carotid plaque thickness measurements available (mean age, 67.29.6 years). Each individual infection was associated with stroke risk after adjusting for other risk factors. The infectious burden index (n861) had a mean of 1.000.35 SD and a median of 1.08. Plaque was present in 52 % of participants (mean, 0.901.04 mm). Infectious burden was associated with maximum carotid plaque thickness (adjusted increase in maximum carotid plaque thickness 0.09 mm; 95 % CI, 0.03 to 0.15 mm per SD increase of infectious burden)