Acetylsalicylic acid (aspirin) is a common nonsteroidal anti-inflam-matory drug used for treatment of pain and arthritis. In the body, acetylsalicylic acid is rapidly deacetylated to form salicylic acid. Both compounds have been proposed as anti-inflammatory agents. Major metabolites of salicylic acid are its acyl and phenolic glucuronide conjugates. Formation of these conjugates, catalyzed by UDP-glucuronosyltransferases (UGTs), decreases the amount of pharmacologically active salicylic acid present. We aimed to identify the UGTs catalyzing the glucuronidation of salicylic acid using both heterologously expressed enzymes and pooled human liver microsomes (HLMs) and to develop a liquid chromatography-tandem mass spectrometry method to quant...
Diethylstilbestrol (DES), a synthetic estrogen, was once prescribed to pregnant women to reduce the ...
Single oral doses of aspirin (ASA, 1,500 mg), sodium salicylate (NaSA, 1,500 mg, 1,200 mg), and sali...
Gypensapogenin C (GPC) is one of the important aglycones of Gynostemma pentaphyllum (GP), which is s...
This article has not been copy ited and formatted. The final version may differ from this version
Nonsteroidal anti-inflammatory drugs (NSAIDs), used for the treat-ment of pain and inflammation, are...
Salicyl acyl glucuronide (SAG) is a significant metabolite of salicylic acid (SA) and aspirin. We ha...
Armillarisin A, a new coumarin derivative isolated from the fungus Armillariella tabescens (Scop. ex...
In recent years, studies of the metabolism of salicylates have been concerned primarily with the con...
Esculetin (6,7-dihydroxycoumarin), is one of coumarin analogs isolated from various plant including ...
Salvianolic acid B is the main active ingredient in salvianolate injection, which is produced by ext...
Flurbiprofen is a nonsteroidal anti-inflammatory drug used as a racemic mixture. Although glucuronid...
Senecionine (SEN) is a representative of the hepatotoxic pyrroliz-idine alkaloids. Although phase I ...
Loxoprofen, a propionic acid derivative, non-steroidal anti-inflammatory drug (NSAID) is a prodrug t...
This study aims to characterize the glucuronidation kinetics of ursolic acid (UA) in human liver mic...
Objective: To explore the glucuronic acid metabolism of acacetin in human liver and intestinal micro...
Diethylstilbestrol (DES), a synthetic estrogen, was once prescribed to pregnant women to reduce the ...
Single oral doses of aspirin (ASA, 1,500 mg), sodium salicylate (NaSA, 1,500 mg, 1,200 mg), and sali...
Gypensapogenin C (GPC) is one of the important aglycones of Gynostemma pentaphyllum (GP), which is s...
This article has not been copy ited and formatted. The final version may differ from this version
Nonsteroidal anti-inflammatory drugs (NSAIDs), used for the treat-ment of pain and inflammation, are...
Salicyl acyl glucuronide (SAG) is a significant metabolite of salicylic acid (SA) and aspirin. We ha...
Armillarisin A, a new coumarin derivative isolated from the fungus Armillariella tabescens (Scop. ex...
In recent years, studies of the metabolism of salicylates have been concerned primarily with the con...
Esculetin (6,7-dihydroxycoumarin), is one of coumarin analogs isolated from various plant including ...
Salvianolic acid B is the main active ingredient in salvianolate injection, which is produced by ext...
Flurbiprofen is a nonsteroidal anti-inflammatory drug used as a racemic mixture. Although glucuronid...
Senecionine (SEN) is a representative of the hepatotoxic pyrroliz-idine alkaloids. Although phase I ...
Loxoprofen, a propionic acid derivative, non-steroidal anti-inflammatory drug (NSAID) is a prodrug t...
This study aims to characterize the glucuronidation kinetics of ursolic acid (UA) in human liver mic...
Objective: To explore the glucuronic acid metabolism of acacetin in human liver and intestinal micro...
Diethylstilbestrol (DES), a synthetic estrogen, was once prescribed to pregnant women to reduce the ...
Single oral doses of aspirin (ASA, 1,500 mg), sodium salicylate (NaSA, 1,500 mg, 1,200 mg), and sali...
Gypensapogenin C (GPC) is one of the important aglycones of Gynostemma pentaphyllum (GP), which is s...