© 2006 Atlas of Genetics and Cytogenetics in Oncology and Haematology Clinics and pathology Disease

Chronic myelogenous leukemia (CML) in accelerated phase (AP-CML). Epidemiology Only one case to date, a female patient, aged a 50 at the time of the AP-CML. Prognosis Chronic phase of CML lasted 2 years before progression into an accelerated phase accompanied with the appearance of the t(7;17); the patient died in blast crisis of the CML 13 months after the AP-CML, 3 years after initial diagnosis of CML. Cytogenetics Cytogenetics morphological A t(9;22)(q34;q11) was, indeed, present. Cytogenetics molecular Cryptic translocation; recognized by multicolor FISH plus locus-specific FISH