Factors influencing quality of life in adult patients with primary brain tumors. Neuro Oncol. 2012;14 Suppl 4:iv8–16. doi:10.1093/ neuonc/nos205

Weperformed a literature reviewwith respect to factors in-fluencing health-related qualityof life (QOL) in adultswith primary brain tumors. A comprehensive, peer-reviewed literature search was performed including studies exam-ining QOL in adults with high-grade gliomas and low-grade gliomas and in routine neuro-oncology practice. The interpretation and implication of QOL domain scores may be different in high-grade, low-grade, and benign brain tumors. Several patient-related, treat-ment-related, and sociocultural factors influence QOL scores. Pretreatment baseline QOL domain scores have been shown to be a predictive parameter for survival function. Implementation of QOL scores in routine clin-ical practice is underused. QOL is an important outcome measure in the treatment of patients with brain tumors and should be incorporated as a surrogate end point along with traditional end points, such as disease-free and overall survival in most current trials