Are Related to Plasma Aldosterone Levels in

Response to Colussi et al. W e read with interest the article byColussi et al. (1) on the relation-ship between insulin resistance, hyperinsulinemia, and aldosterone levels in hypertensive patients. The authors ob-served that the homeostasis model assess-ment index is correlated with plasma aldosterone. They conclude that in pa-tients with hypertension, this relationship might contribute to maintenance of high blood pressure and increase cardiovascu-lar risk. We agree with Colussi et al. on this hypothesis, and we suggest the auto-nomic nervous system as a possible addi-tional biological “link ” in the relationship between insulin resistance, hypertension