Human hematopoietic prostaglandin D synthase inhibitor complex structures

Protein Data Bank accession numbers The atomic coordinates and structure factors of the complex with Cibacrone Blue and the complex with APAS have been deposited with the RCSB Protein Data Bank as 3VI7 and 3VI5, respectively. In mast and Th2 cells, hematopoietic prostaglandin (PG) D synthase (H-PGDS) catalyses the isomeriza-tion of PGH2 in the presence of glutathione (GSH) to produce the allergic and inflammatory mediator PGD2. We determined the X-ray structures of human H-PGDS inhibitor complexes with 1-amino-4