Topoisomerases are crucial to solve DNA topological problems, but they have not been linked to RNA metabolism. Here we show that human topoisomerase 3β (Top3β) is an RNA topoisomerase that biochemically and genetically interacts with FMRP, a protein deficient in Fragile X syndrome and known to regulate translation of mRNAs important for neuronal function and autism. Notably, the FMRP-Top3β interaction is abolished by a disease-associated FMRP mutation, suggesting tha
The Fragile X syndrome (FXS) is a leading cause of intellectual disability (ID) and autism. The dise...
Mental retardation is a frequent cause of intellectual and physical impairment. Several genes associ...
Mental retardation is a frequent cause of intellectual and physical impairment. Several genes associ...
Topoisomerases are crucial to solve DNA topological problems, but they have not been linked to RNA m...
Topoisomerases are crucial for solving DNA topological problems, but they have not been linked to RN...
Human cells contain five topoisomerases in the nucleus and cytoplasm, but which one is the major top...
Implicating particular genes in the generation of complex brain and behavior phenotypes requires mul...
FMRP loss of function causes Fragile X syndrome (FXS) and autistic features. FMRP is a polyribosome-...
Fragile X syndrome – a common form of inherited mental retardation – is caused by the loss of the fr...
Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation 1 gen...
The Fragile X syndrome (FXS) is a leading cause of intellectual disability (ID) and autism. The dise...
Fragile X Syndrome presents with a clinical picture of moderate to severe mental retardation and beh...
Silencing of FMR1 and loss of its gene product FMRP results in Fragile X Syndrome. FMRP binds brain ...
Fragile X syndrome (FXS) is a multi-organ disease that leads to mental retardation, macro-orchidism ...
Topoisomerases solve critical topological problems in DNA metabolism and have long been regarded as ...
The Fragile X syndrome (FXS) is a leading cause of intellectual disability (ID) and autism. The dise...
Mental retardation is a frequent cause of intellectual and physical impairment. Several genes associ...
Mental retardation is a frequent cause of intellectual and physical impairment. Several genes associ...
Topoisomerases are crucial to solve DNA topological problems, but they have not been linked to RNA m...
Topoisomerases are crucial for solving DNA topological problems, but they have not been linked to RN...
Human cells contain five topoisomerases in the nucleus and cytoplasm, but which one is the major top...
Implicating particular genes in the generation of complex brain and behavior phenotypes requires mul...
FMRP loss of function causes Fragile X syndrome (FXS) and autistic features. FMRP is a polyribosome-...
Fragile X syndrome – a common form of inherited mental retardation – is caused by the loss of the fr...
Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation 1 gen...
The Fragile X syndrome (FXS) is a leading cause of intellectual disability (ID) and autism. The dise...
Fragile X Syndrome presents with a clinical picture of moderate to severe mental retardation and beh...
Silencing of FMR1 and loss of its gene product FMRP results in Fragile X Syndrome. FMRP binds brain ...
Fragile X syndrome (FXS) is a multi-organ disease that leads to mental retardation, macro-orchidism ...
Topoisomerases solve critical topological problems in DNA metabolism and have long been regarded as ...
The Fragile X syndrome (FXS) is a leading cause of intellectual disability (ID) and autism. The dise...
Mental retardation is a frequent cause of intellectual and physical impairment. Several genes associ...
Mental retardation is a frequent cause of intellectual and physical impairment. Several genes associ...