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The aim of this study was to evaluate the prevalence of dysphoria/depressive symptoms in mothers of autistic children and to identify correlations between quality of life and socio-demographic profile. An exploratory, descriptive and cross-sectional study was carried out, involving 20 mothers, by applying a socio-demographic profile questionnaire, the Brazilian version of the Beck Depression Inventory (BDI) and the WHOQOL-Bref quality of life scale. Dysphoria/depression criteria were found in 15 % of the mothers. Overall quality of life was evaluated as positive in 70%, however only 40 % were satisfied with their health. The Physical domain (mean=69.4) was perceived as the best, and environment domain as the worst (mean=60.8). Quality of life had a positive association with family income and level of education, and a negative association with depression. Considering the results, further research, especially on those variables that were not statistically relevant, is suggested