Why Test the Children?

Understanding insulin resistance, its complications, and its progression In this issue of Diabetes Care, Goran etal. (1) review the results of their studyof insulin resistance and the compen-satory responses to it in 57 early pubertal children of different racial/ethnic back-grounds. They utilized the frequently sampled intravenous glucose tolerance test (GTT) to assess insulin sensitivity (Si), acute insulin response (AIR), and also cal-culated insulin secretion, hepatic insulin extraction, and insulin clearance. In these children, they found that SI, independent of adiposity, was greater in the Caucasian children than in those of African and His-panic heritage, confirming the observa-tions of others (2–4). They also discovere