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re vi ew ed a rti cl e bjectives: This study aims to assess the vaccina-tion uptake and attitudes of healthcare workers (HCWs) towards seasonal influenza vaccination after incorporating pandemic H1N1 (pH1N1) strain in the vaccines. Methods: A self-administered anonymous questionnaire was issued to nurses registered with any of three col-laborating nursing associations in Hong Kong. Results: A total of 709 questionnaires were completed, representing a response rate of 28.4%. The coverage of 2010/11 seasonal influenza vaccines was 24.1%. It was lower than that of 2009/10 seasonal influenza vaccines, in which pH1N1 strain was not yet included (37.1%), but higher than that of monovalent pH1N1 vaccines intro-duced during the pandemic in 2009 (14.2%). The reduc-tion in the number of vaccinated HCWs varied among sub-groups classified by age, duration of employment, type of contacts with patients or past seasonal influ-enza vaccination record. Early recipients of the vaccine were more likely to have already been vaccinated in the preceding year (odds ratio (OR)=2.95, 95 % confidence interval (95 % CI) =1.15–7.59) and showed an inten-tion to be vaccinated in the following year (OR=2.78, 95 % CI=1.13–6.83). However, incorporation of pH1N1 strain in trivalent seasonal vaccines did not significantly increase the desire for vaccination. Conclusion: In addition to upholding the efficacy and safety standard of influenza vaccines, compliance and acceptance strategies shall be developed as early as possible, and tailored to the needs of differ-ent sub-groups