The interactions of halothane with five major constituents of human blood were studied by equili-brium dialysis. Haemoglobin, albumin, red cell membranes and triglycerides were found to contribute significantly to the solubility, and thus the transport, of halothane in whole blood. At physiological concentrations, y-globulin had no detectable effect on the solubility of halothane. Absorption isotherms of halothane binding to haemoglobin and albumin suggest a possible positive co-operative effect, but complete saturation of the binding sites was not observed even when the aqueous phase was saturated with halothane. The number of halothane molecules bound per albumin molecule was not significantly affected by the presence of oleic acid. For r...
The formation of pentane and anaerobic metabolites of halothane (2-chloro-1,1,1-trifluoroethane and ...
A statistically significant increase in plasma volume was shown to occur during anaes-thesia in twel...
Although instrumental for optimizing their pharmacological activity, a molecular understanding of th...
Halothane (1,1,1-trifluoro-2-bromo-2-chloroethane) is a commonly employed general anaesthetic. A dir...
In a study of the influence of nutritional state on halothane anaesthesia) results were obtained whi...
In vitro measurements were made of the solubility of halothane (about 1%, carried in 5 % carbon diox...
The affinity for oxygen of normal adult human haemoglobin (Hb) solutions was measured in the presenc...
The direct determination by gas chromatography of blood levels of anesthetic agents has been difficu...
A method for quantitative estimation of low concentrations of halothane in blood by gas chromatograp...
The effects of serum protein concentration (SPC) on serum protein/gas partition coefficient and of h...
AbstractTo understand further the weak molecular interactions between inhaled anesthetics and protei...
Na+-dependent uptake of 5-HT (5-hydroxytryptamine) into plasma membrane vesicles derived from bovine...
Purpose: The purpose of this report is to find out the sorption capacity of lyophilised blood produc...
Abstract--Experiments ate described in which a range of halogenated hydrocarbons, labelled with radi...
This study was performed to elucidate the difference in the mechanism of the dissolution of enfluran...
The formation of pentane and anaerobic metabolites of halothane (2-chloro-1,1,1-trifluoroethane and ...
A statistically significant increase in plasma volume was shown to occur during anaes-thesia in twel...
Although instrumental for optimizing their pharmacological activity, a molecular understanding of th...
Halothane (1,1,1-trifluoro-2-bromo-2-chloroethane) is a commonly employed general anaesthetic. A dir...
In a study of the influence of nutritional state on halothane anaesthesia) results were obtained whi...
In vitro measurements were made of the solubility of halothane (about 1%, carried in 5 % carbon diox...
The affinity for oxygen of normal adult human haemoglobin (Hb) solutions was measured in the presenc...
The direct determination by gas chromatography of blood levels of anesthetic agents has been difficu...
A method for quantitative estimation of low concentrations of halothane in blood by gas chromatograp...
The effects of serum protein concentration (SPC) on serum protein/gas partition coefficient and of h...
AbstractTo understand further the weak molecular interactions between inhaled anesthetics and protei...
Na+-dependent uptake of 5-HT (5-hydroxytryptamine) into plasma membrane vesicles derived from bovine...
Purpose: The purpose of this report is to find out the sorption capacity of lyophilised blood produc...
Abstract--Experiments ate described in which a range of halogenated hydrocarbons, labelled with radi...
This study was performed to elucidate the difference in the mechanism of the dissolution of enfluran...
The formation of pentane and anaerobic metabolites of halothane (2-chloro-1,1,1-trifluoroethane and ...
A statistically significant increase in plasma volume was shown to occur during anaes-thesia in twel...
Although instrumental for optimizing their pharmacological activity, a molecular understanding of th...