BACLOFEN TOXICITY INPATIENTS WITH SEVERELY IMPAIRED RENAL FUNCTION

OBJECI1VE: To report the toxic effects of baclofen in patients with severely impaired renal function. DATA SOURCES: From 1991 to 1995, nine patients with severely impaired renal function (2 not receiving dialysis, I undergoing continuous ambulatory peritoneal dialysis [CAPD], and 6 receiving maintenance hemodialysis), who exhibited clinical toxicity after baclofen therapy at our hospital were included for analysis. Another seven cases from the literature obtained by computerized (MEDLINE) and manual (IndexMedicus) search methods published between 1980 and 1995 were also reviewed. INTERVENTION: Among our nine patients, the six undergoing chronic hemodialysis and one not undergoing dialysis received early «48 h) hemodialysis after toxic symptoms developed. The patient undergoing CAPD received late hemodialysis (>72 h), and the other patient who had not undergone dialysis received only supportive care