Topics
pancreatic cancerDisease
phenotypeHistoric place
DNABand
5-azaChemical substance
DNA methylationElection
adenocarcinomaDisease
To investigate whether DNA meth-ylation and the invasive phenotype of pancreatic adenocarcinoma are asso-ciated, we studied the role of methyl-ation in the transcriptional regulation of several matrix metalloproteinases (MMPs) and the effect of 5-aza-2-de-oxycytidine (5Aza-dC), an inhibitor of DNA methylation, on the invasive behavior of pancreatic cancer cells. Using the Boyden chamber in vitro in-vasion assay, we found a statistically significant increase in invasive poten-tial in four of five pancreatic cancer cell lines after treatment with 5Aza-dC. This enhanced invasiveness was asso-ciated with the induction of mRNAs for one or more MMPs critical for tu
subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibito
While the durable anti-tumorigenic effects of 5-AZA-CdR on cancer cells are well known, its effects ...
5-Aza-2'-deoxycytidine (5-AZA-CdR) is an inhibitor of DNA methylation, and its antileukemic activity...
Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatmen...
The mechanism of action of DNA methylation inhibitor 5-aza-2′-deoxycytidine (5-aza-CdR), a potential...
AbstractThe mechanism of action of DNA methylation inhibitor 5-aza-2′-deoxycytidine (5-aza-CdR), a p...
<p>(A) M-/U-MSP analysis of <i>miR-124-1</i> promoter methylation status and stem-loop qRT-PCR analy...
For hepatocellular carcinoma (HCC), effective therapeutic approaches are lacking. As aberrant gene m...
Reversion-inducing cysteine-rich protein with kazal motifs (RECK), a novel tumor suppressor gene tha...
Summary Maspin, which belongs to the serine protease inhibitor (serpin) superfamily, has been propos...
Background: Promoter hyper-methylation of tumor suppressor genes is a common event that occurs in ca...
In order to study the effect of DNA methylation on gene expression, human cancer cell lines were tre...
To explore the possibility of a new therapeutic strategy for leukemia by intervening in the DNA meth...
Maspin, which belongs to the serine protease inhibitor (serpin) superfamily, has been proposed as a ...
While studying on epigenetic regulatory mechanisms (DNA methylation at C-5 of -CpG- cytosine and dem...
subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibito
While the durable anti-tumorigenic effects of 5-AZA-CdR on cancer cells are well known, its effects ...
5-Aza-2'-deoxycytidine (5-AZA-CdR) is an inhibitor of DNA methylation, and its antileukemic activity...
Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatmen...
The mechanism of action of DNA methylation inhibitor 5-aza-2′-deoxycytidine (5-aza-CdR), a potential...
AbstractThe mechanism of action of DNA methylation inhibitor 5-aza-2′-deoxycytidine (5-aza-CdR), a p...
<p>(A) M-/U-MSP analysis of <i>miR-124-1</i> promoter methylation status and stem-loop qRT-PCR analy...
For hepatocellular carcinoma (HCC), effective therapeutic approaches are lacking. As aberrant gene m...
Reversion-inducing cysteine-rich protein with kazal motifs (RECK), a novel tumor suppressor gene tha...
Summary Maspin, which belongs to the serine protease inhibitor (serpin) superfamily, has been propos...
Background: Promoter hyper-methylation of tumor suppressor genes is a common event that occurs in ca...
In order to study the effect of DNA methylation on gene expression, human cancer cell lines were tre...
To explore the possibility of a new therapeutic strategy for leukemia by intervening in the DNA meth...
Maspin, which belongs to the serine protease inhibitor (serpin) superfamily, has been proposed as a ...
While studying on epigenetic regulatory mechanisms (DNA methylation at C-5 of -CpG- cytosine and dem...
subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibito
While the durable anti-tumorigenic effects of 5-AZA-CdR on cancer cells are well known, its effects ...
5-Aza-2'-deoxycytidine (5-AZA-CdR) is an inhibitor of DNA methylation, and its antileukemic activity...
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