HIV/STIs and pregnancy prevention, using a cervical barrier and microbicide

Objectives: 1) HIV prevention, using a mechanical cervical barrier in combination with microbicide. 2) Prevention of pregnancy. 3) Shield the cervix to prevent sperm penetration and Gonorrhea, Chlamydia and HIV virus invasion. Me-thods: We investigated a new FDA approved cervical barrier FemCap (Figure 1). The FemCap is a contraceptive de-vice that is designed with a unique delivery system for microbicides on its cervical and vaginal sides (Figure 2) to en-sure better coverage, and retention of gel on the cervix and vagina. We also compared the acceptability and adherence with the FemCap, and retention of a stained vaginal lubricant when delivered with the FemCap versus the vaginal lu-bricant when delivered using a traditional vaginal applicator (Figure 3). We used the same vaginal applicator utilized in the CAPRISA 004 [1] study, to deliver Tenofovir microbicide. Thirty women compared the use of a vaginal applica-tor to deliver a high viscosity stained vaginal lubricant before and after intercourse, versus the FemCap to deliver the same lubricant once before intercourse. The acceptability and efficacy of this delivery system was evaluated. Results: Forty percent (12) women missed the application of the lubricant with the vaginal applicator before intercourse and 10 % missed it after intercourse. Amongst FemCap users (3) women (10%) missed application of the vaginal lubricant before intercourse and all of them inserted it after intercourse. The stained gel was better retained over the cervix (Figure 4) by single application with the FemCap versus two applications with the traditional applicator (Figure 3)