Case report: Effect of immunoglobulin on pain in Post-Polio Syndrome—Three case reports

License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Study design: Case reports. Setting: University hospital setting. Objective: To analyze the effect of intravenous immunoglobulin on neuropathic and nociceptive pain in three patients with Post-Polio Syndrome (PPS). Materials and Methods: Three patients with PPS and pain who received treatment with 90 g IvIg are described. Results: Before treatment one of the patients had pure neuropathic pain and the other two had a com-bination of neuropathic and nociceptive pain. There was no effect on pain in the patient with pure neuropathic pain and only effect on the nociceptive pain in the patients with a combina-tion of neuropathic and nociceptive pain. Dis-cussion: Pain is one of the most common sym-ptoms in PPS. Previous studies have shown an effect on pain in PPS patients receiving IvIg. The results of the present study point to that the ef-fect on pain is limited to nociceptive pain and that there is no effect on neuropathic pain which leads to increased knowledge of characteriza-tion of responders of IvIg treatment. Conclusion: IvIg treatment treatment reduces nociceptive but not neuropathic pain in PPS patients