Perinatal Exposure of Patas Monkeys to Antiretroviral

Background. Erythrocebus patas (patas) monkeys were used to model antiretroviral (ARV) drug in human immunode-ficiency virus type 1–infected pregnant women. Methods. Pregnant patas dams were given human-equivalent doses of ARVs daily during 50 % of gestation. Mesenchymal cells, cultured from bone marrow of patas offspring obtained at birth and at 1 and 3 years of age, were examined for geno-toxicity, including centrosomal amplification, micronuclei, and micronuclei containing whole chromosomes. Results. Compared with controls, statistically significant increases (P <.05) in centrosomal amplification, micronuclei, and micronuclei containing whole chromosomes were found in mesenchymal cells from most groups of offspring at the 3 time points. Conclusions. Transplacental nucleoside reverse-transcriptas