Clinical and prognostic categorization of extraintestinal nontyphoidal Salmonella infections in infants and

The study included 172 patients, aged 0±15 years, for whom at least 1 nonfecal, nonurinary specimen was culture-positive for nontyphoidal Salmonella. Ninety-®ve percent had positive blood cultures. Immunocompromising diseases were found in 19 % of 74 infants and 77 % of 98 children. Associations between the study factors and outcomes, as localized infection or death, were assessed by logistic regression analysis. Thirty-three patients had localized infec-tions. An adjusted risk factor for development of localized infections was an age of!12 months (). There were 17 deaths. The case-fatality rates were 43 % and 10 % for immunocom-P =.003 promised and 5 % and 0 % for nonimmunocompromised infants and children, respectively. Adjusted risk factors for death were age of!12 months (), inappropriate antimicrobialP =.006 therapy (), meningitis or culture-proven pneumonia due to nontyphoidal SalmonellaP =.014 (), and immunocompromised status (). The clinical courses and prognoses forP =.004 P!.001 infants and children with extraintestinal infection due to nontyphoidal Salmonella can be categorized into 4 groups according to the characteristics of age (infants vs. children) and host status (immunocompromised vs. nonimmunocompromised). Infection with nontyphoidal Salmonella in infants and chil