Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties

Heterocyclic compounds containing the five-membered oxadiazole nucleus possess a diversity of useful biological effects. 1,3,4-Oxadiazole and 3-aroylpropionic acid moi-eties are important because of their versatile biological actions. In particular, compounds bearing the 1,3,4-oxadiazole nucleus are known to have unique antioedema and anti-in-flammatory activities (1–3). Differently substituted oxadiazole moieties have also been found to have other interesting activities such as analgesic (2, 3), antimicrobial (4), anti-tubercular (5), anticonvulsant (6) and anti-hepatitis B viral activities (7). Non-steroidal anti-inflammatory drugs NSAIDs form a class of therapeutic agents that are mos