1874-2416/08 2008 Bentham Open Open Access Quantitative Analysis of Acid-Base Disorders in Patients with Acute on Chronic Respiratory Failure and Acute Respiratory Distress Syndrome. A Prospective, One Center Study

Abstract: Background: With Stewart approach, pH depends on strong ion difference (SIDe), PaCO2 and non volatile weak acids (Atot). This approach might detect complex acid-base disorders undetected by conventional approach. We de-signed this study to describe acid-base disorders with both Stewart and conventional approaches and to compare the diagnostic performance in patients with chronic respiratory failure (CRF) in acute respiratory failure (ARF) or with acute respiratory distress syndrome (ARDS) because they are expected to have complex acid-base disorders. Conventional ap-proach was based on standardized base excess (SBE), bicarbonate (HCO3) and anion gap (AG). Working hypotheses were that in CRF, metabolic alkalosis was associated with respiratory acidosis and in ARDS, Stewart approach was able to identify metabolic acidosis not detected with the conventional approach. Methods: Observational study in a medical ICU of a University hospital on 36 patients with obstructive CRF (CRFo), 36 with non obstructive CRF (CRFno) and 28 with ARDS prospectively included over 8 months. Measurements were per-formed on ICU admission, day 1 and day 2 after admission. Results: Metabolic alkalosis occurred in less than 5 % of samples in CRF patients and in 0 ARDS patient. As compared to CRF patients, ARDS patients exhibited lower SBE, higher AG, lower SIDe and lower Atot. In ARDS, low SIDe was pri-marily due to elevated unidentified anions. Hypoalbuminemia was present in more than 75 % of patients without dif