Comparison of the Broth Microdilution Methods of the European Committee on Antimicrobial Susceptibility Testing and the Clinical

We compared EUCAST and CLSI antifungal susceptibility testing methods for itraconazole, posaconazole, and voriconazole by testing 245 Aspergillus clinical isolates. The essential agreement (EA) between methods was excellent: 100 % (itraconazole), 98.4 % (posaconazole), and 99.6 % (voriconazole) assessing EA at 2 dilutions and 99.6 % (itraconazole), 87.7 % (posaconazole), and 96.3 % (voriconazole) at 1 dilution. The triazole antifungals include the mold-active agents itra-conazole, posaconazole, and voriconazole (2). Each of these agents has good in vitro and in vivo activity against most specie