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Note: +22 is often associated with inv(16)(p13q22) or its equivalents; the existence of trisomy 22 solely is debated. Clinics and pathology Disease Acute non lymphocytic leukemia (ANLL). Phenotype/cell stem origin M4eo ANLL most often in cases associated with inv(16); M4 also, but only in 2/3 of cases, when +22 is apparently without inv(16); and eosinophilia may be missing in the latter case. Epidemiology Young age, both in cases with or without inv(16). Clinics inv(16) may be at increased CNS relapse when +22 i