Leading articles Concentration controlled and concentration

defined clinical trials: do they offer any advantages for antimicrobial chemotherapy? J Antimicrob Chemother 1996; 37: 1-5 The rationale for antimicrobial dosing regi-mens is often difficult to understand, and dosages or dosage intervals are changed or shown to be inappropriate several years after antimicrobials have been marketed (MacGowan et al., 1992; Bauernfeind, 1993; Forrest et al., 19936; Reeves et al., 1995). For example, twice or three times a day dosing with aminoglycosides has recently given way to once daily therapy with resultant debate about therapeutic monitoring and dosing (Cronberg